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Article

Generation of T cells specific for the wild-type sequence p53(264-272) peptide in cancer patients: implications for immunoselection of epitope loss variants.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2000

Hoffmann T K, Nakano K, Elder E M, Dworacki G, Finkelstein S D, Appella E, Whiteside T L, DeLeo A B

Abstract excerpt

Alterations in the p53 gene occur frequently and can lead to accumulation of p53 protein in squamous cell carcinomas of the head and neck (SCCHN). Since accumulation of p53 is associated with enhanced presentation of wild-type sequence (wt) p53 peptides to immune cells, the development of pan vaccines against SCCHN has focused on wt p53 epitopes. We used the HLA-A2.1-restricted wt p53(264-272) epitope to generate...

Read the complete abstract on PubMed

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Share to Cytotoxicity, Immunologic
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to HLA-A2 Antigen

Share to Immunodominant Epitopes

Share to Staining and Labeling

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 11067956
DOI: 10.4049/jimmunol.165.10.5938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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