Article
p53: a potential target antigen for immunotherapy of cancer.
Annals of the New York Academy of Sciences - 1 Jun 2000
Offringa R, Vierboom M P, van der Burg S H, Erdile L, Melief C J
Abstract excerpt
Approximately 50% of all human malignancies exhibit mutation and aberrant expression of p53, making this protein an interesting candidate target for immunotherapy of cancer. Mutations in p53 are highly diverse. Therefore, targeting of determinants within the wild-type p53 sequence appears most practical. Despite the fact that p53 is ubiquitously expressed, adoptive immunotherapy of tumor-bearing mice with...
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