Article
Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 1995
Iwaya K, Tsuda H, Fujita S, Suzuki M, Hirohashi S
Abstract excerpt
BACKGROUND: Nuclear accumulation of p53 protein in breast cancer cells is generally accepted as a marker for the presence of p53 gene mutation and as an indicator of poor prognosis. Mutation in the p53 gene has been shown to cause conformational change in the p53 protein, which gives rise to a co...
Topics
- Aged
- Breast Neoplasms
- Cell Nucleus
- Female
- Genes
- HSP70 Heat-Shock Proteins
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Polymorphism, Single-Stranded Conformational
- Precipitin Tests
- Staining and Labeling
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53