Article
An Sp1 binding site and the minimal promoter contribute to overexpression of the cytokeratin 18 gene in tumorigenic clones relative to that in nontumorigenic clones of a human carcinoma cell line.
Molecular and cellular biology - 1 May 1995
Gunther M, Frebourg T, Laithier M, Fossar N, Bouziane-Ouartini M, Lavialle C, Brison O
Abstract excerpt
Clones of cells tumorigenic or nontumorigenic in nude mice have been previously isolated from the SW613-S human colon carcinoma cell line. We have already reported that tumorigenic cells overexpress the cytokeratin 18 (K18) gene in comparison with nontumorigenic cells and that this difference is mainly due to a transcriptional regulation. We now report that a 2,532-bp cloned human K18 gene promoter drives the...
Topics
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA, Neoplasm
- Gene Expression
- Humans
- Keratins
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic