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Article

Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE study.

Nitric oxide : biology and chemistry - 30 May 2014

Levinsson Anna, Olin Anna-Carin, Björck Lena, Rosengren Annika, Nyberg Fredrik

Abstract excerpt

OBJECTIVE: Nitric oxide synthase (NOS) exists in three distinct isoforms, each encoded by a specific gene: neuronal NOS (NOS1 gene), inducible NOS (NOS2 gene) and endothelial NOS (NOS3 gene). Single nucleotide polymorphisms (SNPs) in NOS genes have been associated with cardiovascular pathology. We aimed to comprehensively investigate which NOS gene variants are most strongly associated with coronary heart disease...

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Identifiers

PMID: 24713495
DOI: 10.1016/j.niox.2014.03.164

Genes

NOS1
NOS3
NOS2

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