Article
Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.
Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008
Madry Christian, Betz Heinrich, Geiger Jörg R P, Laube Bodo
Abstract excerpt
Coassembly of the glycine-binding NMDA receptor subunits NR1 and NR3A results in excitatory glycine receptors of low efficacy. Here, we report that micromolar concentrations of the divalent cation Zn(2+) produce a 10-fold potentiation of NR1/NR3A receptor responses, which resembles that seen upon antagonizing glycine binding to the NR1 subunit. Coapplication of both Zn(2+) and NR1 antagonist caused a supralinear...
Topics
- Animals
- Binding Sites
- Electrophysiology
- Glycine
- Microinjections
- Mutation
- Oocytes
- RNA
- Receptors, Glycine
- Receptors, N-Methyl-D-Aspartate
- Xenopus laevis
- Zinc