Article
MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.
Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015
Rosso Jean-Pierre, Schwarz Jürgen R, Diaz-Bustamante Marcelo, Céard Brigitte, Gutiérrez José M, Kneussel Matthias, Pongs Olaf, Bosmans Frank, Bougis Pierre E
Abstract excerpt
GABAA receptors shape synaptic transmission by modulating Cl(-) conductance across the cell membrane. Remarkably, animal toxins that specifically target GABAA receptors have not been identified. Here, we report the discovery of micrurotoxin1 (MmTX1) and MmTX2, two toxins present in Costa Rican co...
Topics
- Amino Acid Sequence
- Animals
- Elapid Venoms
- Elapidae
- HEK293 Cells
- Hippocampus
- Humans
- Ion Channel Gating
- Kinetics
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Nerve Net
- Neurons