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Article

MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Rosso Jean-Pierre, Schwarz Jürgen R, Diaz-Bustamante Marcelo, Céard Brigitte, Gutiérrez José M, Kneussel Matthias, Pongs Olaf, Bosmans Frank, Bougis Pierre E

Abstract excerpt

GABAA receptors shape synaptic transmission by modulating Cl(-) conductance across the cell membrane. Remarkably, animal toxins that specifically target GABAA receptors have not been identified. Here, we report the discovery of micrurotoxin1 (MmTX1) and MmTX2, two toxins present in Costa Rican coral snake venom that tightly bind to GABAA receptors at subnanomolar concentrations. Studies with recombinant and...

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Identifiers

PMID: 25675485
DOI: 10.1073/pnas.1415488112
PMCID: PMC4345566

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Source receipt: pubmed, retrieved 7 Sept 2026.

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