Article
Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.
Journal of neurochemistry - 1 Nov 1998
Lynch J W, Jacques P, Pierce K D, Schofield P R
Abstract excerpt
Molecular mechanisms of zinc potentiation were investigated in recombinant human alpha1 glycine receptors (GlyRs) by whole-cell patch-clamp recording and [3H]strychnine binding assays. In the wild-type (WT) GlyR, 1 microM zinc enhanced the apparent binding affinity of the agonists glycine and tau...
Topics
- Cell Line
- Chloride Channels
- Drug Synergism
- Electrophysiology
- Glycine
- Glycine Agents
- Humans
- Mutation
- Receptors, Glycine
- Strychnine
- Taurine
- Zinc