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Article

Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.

Journal of neurochemistry - 1 Nov 1998

Lynch J W, Jacques P, Pierce K D, Schofield P R

Abstract excerpt

Molecular mechanisms of zinc potentiation were investigated in recombinant human alpha1 glycine receptors (GlyRs) by whole-cell patch-clamp recording and [3H]strychnine binding assays. In the wild-type (WT) GlyR, 1 microM zinc enhanced the apparent binding affinity of the agonists glycine and taurine and reduced their concentrations required for half-maximal activation. Thus, in the WT GlyR, zinc potentiation...

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Source

Identifiers

PMID: 9798943
DOI: 10.1046/j.1471-4159.1998.71052159.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways.PMID 9798943Read ↗

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