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Article

Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer.

PLoS genetics - 1 Jul 2009

Kim Jongchan, Eltoum Isam-Eldin A, Roh Meejeon, Wang Jie, Abdulkadir Sarki A

Abstract excerpt

In human somatic tumorigenesis, mutations are thought to arise sporadically in individual cells surrounded by unaffected cells. This contrasts with most current transgenic models where mutations are induced synchronously in entire cell populations. Here we have modeled sporadic oncogene activation using a transgenic mouse in which c-MYC is focally activated in prostate luminal epithelial cells. Focal c-MYC...

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Share to Apoptosis
Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Prostatic Neoplasms

Share to Protein Binding

Share to Proto-Oncogene Proteins c-myc

Share to PTEN Phosphohydrolase

Source

Open in PubMed Open full text

Identifiers

PMID: 19578399
DOI: 10.1371/journal.pgen.1000542
PMCID: PMC2697385

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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