p53, mutation frequency and apoptosis in the murine small intestine.

doi:10.1038/sj.onc.1201040

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Article

p53, mutation frequency and apoptosis in the murine small intestine.

Oncogene - 1 May 1997

Clarke A R, Howard L A, Harrison D J, Winton D J

Abstract excerpt

Normal function of the p53 gene is integral to the cellular response to genotoxic stress. One prediction arising from this is that p53 deficiency results in an increased mutation frequency. However, limited evidence has been produced in support of this idea. In order to further investigate the in...

Topics

Animals
Apoptosis
Epithelial Cells
Epithelium
Genes, p53
Genotype
Intestine, Small
Mice
Mice, Knockout
Mutation
Organ Specificity
Receptors, Mitogen
Tumor Suppressor Protein p53

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