Article
Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function.
Genes & development - 1 Feb 1995
Imakado S, Bickenbach J R, Bundman D S, Rothnagel J A, Attar P S, Wang X J, Walczak V R, Wisniewski S, Pote J, Gordon J S
Abstract excerpt
To study the effects of retinoic acid on the skin in vivo, we have subverted the activity of endogenous receptors by targeting expression of a dominant negative mutant of retinoic acid receptor alpha (RAR alpha) to the epidermis of transgenic mice. At birth, mice expressing the mutant RAR alpha t...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Keratinocytes
- Lipid Metabolism
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Receptors, Retinoic Acid
- Skin
- Water