Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.

doi:10.1084/jem.181.3.1157

Article

Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus.

1 Mar 1995

Abstract excerpt

Anti-DNA antibodies, specifically those that stain nuclei in a homogenous nuclear (HN) fashion, are diagnostic of systemic lupus erythematosus (SLE) and the MRL-lpr/lpr SLE murine model. We have used a heavy chain transgene that increases the frequency of anti-HN antibodies to address whether their production in SLE is the consequence of a defect in B cell tolerance. Anti-HN B cells were undetectable in...

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