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Article

Persistence of functionally compromised anti-double-stranded DNA B cells in the periphery of non-autoimmune mice.

International immunology - 1 Nov 1997

Roark J H, Bui A, Nguyen K A, Mandik L, Erikson J

Abstract excerpt

Both anti-single-stranded (ss) and anti-double-stranded (ds) DNA antibodies are associated with the autoimmune disease systemic lupus erythematosus (SLE), but only anti-dsDNA antibodies are considered one of the diagnostic criteria. Using Ig transgenes coding for anti-DNA we have determined the fate of anti-dsDNA B cells in a non-autoimmune environment. In a Rag-2 wild-type background, B cells expressing the...

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PMID: 9418123
DOI: 10.1093/intimm/9.11.1615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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