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Article

Catalytic activity and transformation potential of v-Src require arginine 385 in the substrate binding pocket.

Oncogene - 5 Jan 1995

Senften M, Schenker G, Sowadski J M, Ballmer-Hofer K

Abstract excerpt

Tyrosine kinase are important mediators of signal transduction in eukaryotic cells. In order to better understand the mechanism of catalysis we studied a set of mutants of the prototype tyrosine kinase, the c-Src protein, a homologue of the Rous Sarcoma virus oncogene. Based on an X-ray structure of cAMP-dependent protein kinase (cAPK) we mutated an arginine residue conserved in subdomain VI of all known kinases...

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PMID: 7529917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Catalytic activity and transformation potential of v-Src require arginine 385 in the substrate binding pocket.PMID 7529917Read ↗

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