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Article

Contribution of transplantations to the understanding of the role of the PLP gene.

Neurochemical research - 1 Aug 1994

Lachapelle F, Gumpel M, Baumann N

Abstract excerpt

We present an overview of the results obtained in a cross-transplantation system using respectively controls, jimpy (jp), and shiverer mutant mice as donors and recipients. Homochronic transplantations (O days into O days) demonstrated that jp environment is non-toxic for non-jp cells and that, contrary to in vitro, jp oligodendrocytes phenotype cannot be modified by environmental factors at this age....

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Identifiers

PMID: 7528353
DOI: 10.1007/BF00968720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contribution of transplantations to the understanding of the role of the PLP gene.PMID 7528353Read ↗

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Glial transplants: an in vivo analysis of extrinsic and intrinsic determinants of dysmyelination in genetic variants.Semantic proximity Read ↗

What have we learned about the jimpy phenotype expression by intracerebral transplantations?Semantic proximity Read ↗

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.Semantic proximity Read ↗

Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene.Semantic proximity Read ↗

Rumpshaker behaves like juvenile-lethal Plp mutations when combined with shiverer in double mutant mice.Semantic proximity Read ↗

Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.Semantic proximity Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.Semantic proximity Read ↗

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