Article
The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.
Journal of cellular biochemistry - 1 Mar 2015
Valenti Fabio, Ibetti Jessica, Komiya Yuko, Baxter Melissa, Lucchese Anna Maria, Derstine Lauren, Covaciu Claudia, Rizzo Valeria, Vento Renza, Russo Giuseppe, Macaluso Marcella, Cotelli Franco, Castiglia Daniele, Gottardi Cara J, Habas Raymond, Giordano Antonio, Bellipanni Gianfranco
Abstract excerpt
β-Catenin is a central effector of the Wnt pathway and one of the players in Ca(+)-dependent cell-cell adhesion. While many wnts are present and expressed in vertebrates, only one β-catenin exists in the majority of the organisms. One intriguing exception is zebrafish that carries two genes for β-catenin. The maternal recessive mutation ichabod presents very low levels of β-catenin2 that in turn affects dorsal...
Topics
- Animals
- Antibody Specificity
- Axin Protein
- Blastula
- Cell Nucleus
- Embryonic Development
- Female
- Gene Expression Regulation, Developmental
- Genes, Dominant