Article
Mechanism of mast cell deficiency in mutant mice of mi/mi genotype: an analysis by co-culture of mast cells and fibroblasts.
Blood - 15 Mar 1990
Ebi Y, Kasugai T, Seino Y, Onoue H, Kanemoto T, Kitamura Y
Abstract excerpt
Mutant mice of mi/mi genotype are osteopetrotic and are deficient in mast cells. The osteopetrosis of mi/mi mice can be cured by bone marrow transplantation from congenic normal (+/+) mice, and therefore, the cause of the osteopetrosis is attributed to a defect of osteoclasts. Since both osteocla...
Topics
- Animals
- Cell Division
- Cells, Cultured
- Female
- Fibroblasts
- Genotype
- Interleukin-3
- Interleukin-4
- Male
- Mast Cells
- Mice
- Mice, Mutant Strains
- Spleen