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Article

Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002

Gabant Philippe, Forrester Lesley, Nichols Jennifer, Van Reeth Thierry, De Mees Christelle, Pajack Bernard, Watt Alistair, Smitz Johan, Alexandre Henri, Szpirer Claude, Szpirer Josiane

Abstract excerpt

The alpha-fetoprotein gene (Afp) is a member of a multigenic family that comprises the related genes encoding albumin, alpha-albumin, and vitamin D binding protein. The biological role of this major embryonic serum protein is unknown although numerous speculations have been made. We have used gene targeting to show that AFP is not required for embryonic development. AFP null embryos develop normally, and...

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Identifiers

PMID: 12297623
DOI: 10.1073/pnas.202215399
PMCID: PMC130551

Genes

AFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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