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Article

In vitro characteristics of early epidermal progenitors isolated from keratin 14 (K14)-deficient mice: Insights into the role of keratin 17 in mouse keratinocytes

1 Sept 1999

Abstract excerpt

Keratin 14 (K14) is believed to play a pivotal role in the maintenance of epidermal cell shape and contributing to their resistance to mechanical trauma, thereby protecting the cells from lysing. Mice harboring a K14 null mutation produce phenotypic characteristics of epidermolysis bullosa simplex, a skin blistering disease (Lloyd et al., 1995, J Cell Biol 129:1329-1344). K14 null animals die several days after...

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PMID: 10430181
DOI: 10.1002/(sici)1097-4652(199909)180:3<409::aid-jcp12>3.0.co;2-v

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