Article
Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis.
Journal of autoimmunity - 1 Feb 2017
Chung Brian K, Guevel Bardia T, Reynolds Gary M, Gupta Udatha D B R K, Henriksen Eva Kristine Klemsdal, Stamataki Zania, Hirschfield Gideon M, Karlsen Tom Hemming, Liaskou Evaggelia
Abstract excerpt
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated biliary diseases that demonstrate prominent and restricted genetic association with human leukocyte antigen (HLA) alleles. In PBC, anti-mitochondrial antibodies (AMA) are specific and used as diagnostic biomarkers. PSC-relevant auto-antibodies remain controversial despite a distinct HLA association that mirrors...
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