Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A fast and robust dual-label nonradioactive oligonucleotide ligation assay for detection of factor V Leiden.

Thrombosis and haemostasis - 1 Oct 1997

Chakravarty A, Hansen T S, Hørder M, Kristensen S R

Abstract excerpt

Activated protein C resistance is in almost all cases caused by the factor V Leiden mutation (FV:R506Q). Due to the high prevalence and clinical significance of the mutation reliable methods suited for processing large sets of samples are in demand. We here present the oligonucleotide ligation assay (OLA) with lanthanide labeled oligonucleotides for the detection of FV Leiden. The assay is based on time resolved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Factor V
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oligonucleotide Probes

Share to Point Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 9364990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A fast and robust dual-label nonradioactive oligonucleotide ligation assay for detection of factor V Leiden.PMID 9364990Read ↗

Dual-color detection of DNA sequence variants by ligase-mediated analysis.Semantic proximity Read ↗

Factor V Leiden mutation screened by PCR and detected with lanthanide-labeled probes.Semantic proximity Read ↗

A dual label oligonucleotide ligation assay for detection of the CYP2C19*1, CYP2C19*2, and CYP2C19*3 alleles involving time-resolved fluorometry.Semantic proximity Read ↗

A homogeneous europium cryptate-based assay for the diagnosis of mutations by time-resolved fluorescence resonance energy transfer.Semantic proximity Read ↗

Robust nonradioactive oligonucleotide ligation assay to detect a common point mutation in the CYP2D6 gene causing abnormal drug metabolism.Semantic proximity Read ↗

Single-well genotyping of diallelic sequence variations by a two-color ELISA-based oligonucleotide ligation assay.Semantic proximity Read ↗

Oligonucleotide ligation assay for detection of the factor V mutation (Arg506-->Gln) causing protein C resistance.Semantic proximity Read ↗

Oligonucleotide ligation assay: applications to molecular diagnosis of inherited disorders.Semantic proximity Read ↗

Simultaneous detection of two cystic fibrosis alleles using dual-label time-resolved fluorometry.Semantic proximity Read ↗

Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay.Semantic proximity Read ↗

New labelling technology for molecular probes applied to the ligation detection reaction-universal array system.Semantic proximity Read ↗

Development of a ligase detection reaction/CGE method using a LIF dual-channel detection system for direct identification of allelic composition of mutated DNA in a mixed population of excess wild-type DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.