Article
A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 1999
Stockbauer K E, Magoun L, Liu M, Burns E H, Gubba S, Renish S, Pan X, Bodary S C, Baker E, Coburn J, Leong J M, Musser J M
Abstract excerpt
The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes. Sequence analysis of the speB gene from 200 group A Streptococcus isolates collected worl...
Topics
- Alleles
- Animals
- Bacterial Proteins
- CHO Cells
- Cell Adhesion
- Cricetinae
- Cysteine Endopeptidases
- Endothelium, Vascular
- Genetic Variation
- Humans
- Integrins