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Article

Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci

1 Oct 2000

Abstract excerpt

Primary infection of the human host by group A streptococci (GAS) most often involves either the epidermis of the skin or the oropharyngeal mucosa. A humanized in vivo model for impetigo was used to investigate the basis for host tissue tropism among GAS. Disruption of the speB gene (encoding for a secreted cysteine proteinase) led to a loss of virulence for two impetigo-derived strains (M-types 33 and 53), as...

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PMID: 11069651
DOI: 10.1046/j.1365-2958.2000.02144.x

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