Article
Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture.
Mutation research - 1 Jun 1994
Piatti E, Marabini L, Chiesara E
Abstract excerpt
The pesticides benomyl, a benzimidazole fungicide, and pirimiphos-methyl, an organophosphorus insecticide, were tested separately and in combination at a ratio of 6:1, a mixture frequently found in foodstuffs by residual analysis, to determine their possible genotoxic action. The effect was measured by the micronucleus test carried out on cultured rat hepatocytes stimulated to proliferate by epidermal growth...
Topics
- Animals
- Benomyl
- Cells, Cultured
- Dose-Response Relationship, Drug
- Insecticides
- Liver
- Micronucleus Tests
- Mutation
- Organothiophosphorus Compounds
- Rats