Thimerosal induces micronuclei in the cytochalasin B block micronucleus test with human lymphocytes.

doi:10.1007/s00204-002-0405-z

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Article

Thimerosal induces micronuclei in the cytochalasin B block micronucleus test with human lymphocytes.

Archives of toxicology - 1 Jan 2003

Westphal Götz A, Asgari Soha, Schulz Thomas G, Bünger Jürgen, Müller Michael, Hallier Ernst

Abstract excerpt

Thimerosal is a widely used preservative in health care products, especially in vaccines. Due to possible adverse health effects, investigations on its metabolism and toxicity are urgently needed. An in vivo study on chronic toxicity of thimerosal in rats was inconclusive and reports on genotoxic effects in various in vitro systems were contradictory. Therefore, we reinvestigated thimerosal in the cytochalasin B...

Topics

Actin Cytoskeleton
Cell Division
Cytochalasin B
Dose-Response Relationship, Drug
Drug Antagonism
Genotype
Glutathione Transferase
Humans
Lymphocytes
Micronucleus Tests
Mutagens
Polymorphism, Genetic
Preservatives, Pharmaceutical
Thimerosal

Source

Open in PubMed

Identifiers

PMID: 12491041
DOI: 10.1007/s00204-002-0405-z

Genes

GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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