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Article

Microbial mutagenicity and in vitro chromosome aberration induction by FK973, a new antitumor agent.

Mutation research - 1 Jun 1994

Hirai O, Miyamae Y, Hattori Y, Takashima M, Miyamoto A, Zaizen K, Mine Y

Abstract excerpt

The genotoxic activity of a new antitumor agent, FK973, was compared with that of mitomycin C (MMC) in eukaryotic and prokaryotic cells. In chromosome aberration tests using Chinese hamster fibroblast Don cells, FK973 induced a dose-related increase of aberrant cells after 6 h-pulse treatments, and the minimum effective concentrations with and without S9 were 0.625 and 0.0625 micrograms/ml, respectively. The...

Topics

Animals
Antineoplastic Agents
Biotransformation
Cells, Cultured
Chromosome Aberrations
Cricetinae
Cricetulus
Mitomycin
Mutagenicity Tests
Mutation
Oxazines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella typhimurium

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Identifiers

PMID: 7515469
DOI: 10.1016/0165-7992(94)90066-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7515469-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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