Assessment of the potential genotoxic risk of Phyllantus orbicularis HBK aqueous extract using in vitro and in vivo assays.

doi:10.1016/s0378-4274(02)00255-2

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Article

Assessment of the potential genotoxic risk of Phyllantus orbicularis HBK aqueous extract using in vitro and in vivo assays.

Toxicology letters - 15 Dec 2002

Sánchez-Lamar Angel, Fuentes Jorge Luís, Fonseca Gladys, Cápiro Nancy, Ferrer Mirle, Alonzo Alena, Baluja Ligia, Cozzi Renata, De Salvia Rosella, Fiore Mario, Llagostera Montserrat

Abstract excerpt

Phyllanthus orbicularis HBK is an endemic Cuban plant whose aqueous extract has been proposed as an effective drug for the treatment of viral diseases. In addition, antimutagenic properties of this extract have also been reported. In the present study, the genotoxicity of this plant extract was assessed using different in vitro and in vivo assays. Results from SOS gene induction, gene reversion and conversion,...

Topics

Anaphase
Animals
CHO Cells
Chromosome Aberrations
Cricetinae
DNA
DNA Damage
Dose-Response Relationship, Drug
Drosophila melanogaster
Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Mutagenicity Tests

Mutation

Phyllanthus

Plant Extracts

SOS Response, Genetics

Saccharomyces cerevisiae

Salmonella typhimurium

Source

Open in PubMed

Identifiers

PMID: 12425959
DOI: 10.1016/s0378-4274(02)00255-2

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