Article
Interleukin 2-independent interleukin 7 activity enhances cytotoxic immune response of HIV-1-infected individuals.
AIDS research and human retroviruses - 1 Feb 1994
Carini C, Essex M
Abstract excerpt
Virus-specific cytotoxic T lymphocytes (CTLs), which kill virus-infected cells, are thought to be a major host defense against viral infections. The addition of interleukin 7 (IL-7) at the onset of mitogen-stimulated cultures resulted in a marked (up to threefold) augmentation of env-specific cytotoxicity in human immunodeficiency virus type 1 (HIV-1)-infected individuals (p < 0.001). Addition of IL-7 on day 3 or...
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