Article
Interleukin-2 inhibits HIV-1 replication in some human T cell lymphotrophic virus-1-infected cell lines via the induction and incorporation of APOBEC3G into the virion.
The Journal of biological chemistry - 14 Jun 2013
Oguariri Raphael M, Dai Lue, Adelsberger Joseph W, Rupert Adam, Stevens Randy, Yang Jun, Huang Dawei, Lempicki Richard A, Zhou Ming, Baseler Michael W, Lane H Clifford, Imamichi Tomozumi
Abstract excerpt
IL-2 has been used in culture of primary T cells to maintain cell proliferation. We have previously reported that IL-27 inhibits HIV-1 replication in primary T cells in the presence of IL-2. To gain a better understanding of the mechanisms involved in this inhibitory effect, we attempted to investigate in detail the effects of IL-27 and IL-2 using several cell lines. Unexpectedly, IL-27 did not inhibit HIV-1 in T...
Topics
- APOBEC-3G Deaminase
- CD4 Antigens
- Cell Line
- Cytidine Deaminase
- Enzyme Induction
- Gene Knockdown Techniques
- HIV-1
- Humans
- Interleukin-2
- Mutation