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Potential Role for IL-7 in Fas-Mediated T Cell Apoptosis During HIV Infection

1 Apr 2007

Abstract excerpt

IL-7 promotes survival of resting T lymphocytes and induces T cell proliferation in lymphopenic conditions. As elevated IL-7 levels occur in HIV-infected individuals in addition to high Fas expression on T cells and increased sensitivity to Fas-induced apoptosis, we analyzed whether IL-7 has a regulatory role in Fas-mediated T cell apoptosis. We show that IL-7 up-regulates Fas expression on naive and memory T...

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PMID: 17404319
DOI: 10.4049/jimmunol.178.8.5340

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