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Interleukin 7 reduces the levels of spontaneous apoptosis in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells from HIV-1-infected individuals

7 Feb 2007

Abstract excerpt

Apoptosis has been suggested as one of the major mechanisms of CD4+ T cell depletion during the course of HIV type 1 (HIV-1) infection. Here, we show that interleukin 7 (IL-7), a nonredundant cytokine that plays essential roles in the generation and homeostasis of the T cell compartment of the immune system, exerts strong antiapoptotic effects ex vivo on both CD4+ and CD8+ T cells derived from HIV-1-infected...

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PMID: 17284597
DOI: 10.1073/pnas.0610775104

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