Article
Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1.
Neuron - 1 Apr 1994
Ignelzi M A, Miller D R, Soriano P, Maness P F
Abstract excerpt
The nonreceptor tyrosine protein kinases pp60c-src, p59fyn, and pp62c-yes are localized in growth cones of developing neurons, but their function is undefined. To determine whether these tyrosine kinases were capable of regulating substrate-dependent axon growth, cultures of cerebellar neurons fr...
Topics
- Animals
- Cell Adhesion Molecules, Neuronal
- Cells, Cultured
- Cerebellum
- Immunoblotting
- Laminin
- Leukocyte L1 Antigen Complex
- Mice
- Mice, Inbred C57BL
- Mutation
- Neurites
- Neurons
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins pp60(c-src)
- Tyrosine