Article
The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2002
Thelen Karsten, Kedar Vishram, Panicker Anitha K, Schmid Ralf-Steffen, Midkiff Bentley R, Maness Patricia F
Abstract excerpt
The L1 adhesion molecule regulates axon growth and is mutated in the X-linked mental retardation syndrome CRASH (acronym for corpus callosum agenesis, retardation, aphasia, spastic paraplegia, hydrocephalus). A novel role for L1 as a potentiator of neuronal cell migration to extracellular matrix proteins through beta1 integrins and intracellular signaling to mitogen-activated protein (MAP) kinase was identified....
Topics
- Animals
- Antibodies
- Cell Line
- Cell Movement
- Cerebellum
- Endocytosis
- Extracellular Matrix Proteins
- Humans
- Integrin beta1
- Integrins
- Leukocyte L1 Antigen Complex
- MAP Kinase Signaling System
- Membrane Glycoproteins