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Article

The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 2002

Thelen Karsten, Kedar Vishram, Panicker Anitha K, Schmid Ralf-Steffen, Midkiff Bentley R, Maness Patricia F

Abstract excerpt

The L1 adhesion molecule regulates axon growth and is mutated in the X-linked mental retardation syndrome CRASH (acronym for corpus callosum agenesis, retardation, aphasia, spastic paraplegia, hydrocephalus). A novel role for L1 as a potentiator of neuronal cell migration to extracellular matrix proteins through beta1 integrins and intracellular signaling to mitogen-activated protein (MAP) kinase was identified....

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Identifiers

PMID: 12077189
PMCID: PMC6757736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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