Article
Fluctuation test for two-stage mutations: application to gene amplification.
Mutation research - 1 Apr 1994
Kimmel M, Axelrod D E
Abstract excerpt
The determination of mutation rates is an important experimental procedure for characterizing mutation processes. The accepted method of determining mutation rates, the fluctuation test, was introduced by Luria and Delbrück in 1943. Since then it has been applied to various microorganisms and cells. The Luria-Delbrück test is based on a restrictive hypothesis of mutations being due to single irreversible events....
Topics
- Animals
- Gene Amplification
- Humans
- Models, Genetic
- Mutation