Article
Mucin-like Region of Herpes Simplex Virus Type 1 Attachment Protein Glycoprotein C (gC) Modulates the Virus-Glycosaminoglycan Interaction.
The Journal of biological chemistry - 28 Aug 2015
Altgärde Noomi, Eriksson Charlotta, Peerboom Nadia, Phan-Xuan Tuan, Moeller Stephanie, Schnabelrauch Matthias, Svedhem Sofia, Trybala Edward, Bergström Tomas, Bally Marta
Abstract excerpt
Glycoprotein C (gC) mediates the attachment of HSV-1 to susceptible host cells by interacting with glycosaminoglycans (GAGs) on the cell surface. gC contains a mucin-like region located near the GAG-binding site, which may affect the binding activity. Here, we address this issue by studying a HSV-1 mutant lacking the mucin-like domain in gC and the corresponding purified mutant protein (gCΔmuc) in cell culture...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.