The relative contributions of transcription and translation to plasmid DNA supercoiling in Salmonella typhimurium.

Abstract excerpt

Mutations affecting DNA topoisomerase I (topA) in Salmonella typhimurium were isolated and graded on the basis of their ability to reverse the effects of gyrB mutations on his operon expression. Different topA and gyrB alleles (in otherwise isogenic strains) were used to gather insights into the transcription-dependent variability of plasmid DNA-linking deficit in growing bacteria. This study showed that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Molecular Sequence Data
• Share to Mutation
• Share to Alleles