Article
Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes.
Blood - 1 Apr 2001
Kambe N, Kambe M, Kochan J P, Schwartz L B
Abstract excerpt
Human mast cells in adult tissues have been thought to have limited, if any, proliferative potential. The current study examined mast cells obtained from adult skin and cultured in serum-free medium with recombinant human stem cell factor. During the first 4 weeks of culture, the percentages of mast cells increased from 10 to almost 100. After 8 weeks, a 150-fold increase in the number of mast cells was observed....
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