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Resistance detected by pyrosequencing following zidovudine monotherapy for prevention of HIV-1 mother-to-child-transmission.

AIDS (London, England) - 31 Jul 2015

Olson Scott C, Ngo-Giang-Huong Nicole, Beck Ingrid, Deng Wenjie, Britto Paula, Shapiro David E, Bumgarner Roger E, Mullins James I, Van Dyke Russell B, Jourdain Gonzague, Frenkel Lisa M

Abstract excerpt

To prevent mother-to-child-transmission of HIV-1, the 2010 WHO guidelines recommended prenatal zidovudine (ZDV) monotherapy (option A). To determine if ZDV monotherapy selects for HIV resistance in antiretroviral-naive women during pregnancy, specimens from 50 individuals were examined using pyrosequencing. ZDV-resistance mutations were detected at delivery in seven women (14%, 95% confidence interval 6.6-26.5%)....

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Identifiers

PMID: 26244386
DOI: 10.1097/QAD.0000000000000737
PMCID: PMC4618483

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Source receipt: pubmed, retrieved 7 Sept 2026.

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