Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120.

doi:10.1128/JVI.66.2.848-856.1992

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120.

Journal of virology - 1 Feb 1992

Fung M S, Sun C R, Gordon W L, Liou R S, Chang T W, Sun W N, Daar E S, Ho D D

Abstract excerpt

Two monoclonal antibodies designated BAT085 and G3-136 were raised by immunizing BALB/c mice with gp120 purified from human immunodeficiency virus type 1 (HIV-1) IIIB-infected H9 cell extracts. Among three HIV-1 laboratory isolates (IIIB, MN, and RF), BAT085 neutralized only IIIB infection of CEM-SS cells, whereas G3-136 neutralized both IIIB and RF. These antibodies also neutralized a few primary HIV-1 isolates...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Binding Sites, Antibody
Binding, Competitive
Cell Line
Enzyme-Linked Immunosorbent Assay
Epitopes
Genetic Variation
HIV Envelope Protein gp120
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kinetics

Models, Structural

Molecular Sequence Data

Neutralization Tests

Peptides

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 1370558
DOI: 10.1128/JVI.66.2.848-856.1992
PMCID: PMC240785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120.PMID 1370558Read ↗

Characterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domainSemantic proximity Read ↗

The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates.Semantic proximity Read ↗

A human monoclonal antibody to a complex epitope in the V3 region of gp120 of human immunodeficiency virus type 1 has broad reactivity within and outside clade BSemantic proximity Read ↗

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.Semantic proximity Read ↗

Molecular Characterization of Five Neutralizing Anti-HIV Type 1 Antibodies: Identification of Nonconventional D Segments in the Human Monoclonal Antibodies 2G12 and 2F5Semantic proximity Read ↗

Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus type 1 by using monoclonal antibodiesSemantic proximity Read ↗

Monoclonal antibodies to the extracellular domain of HIV-1IIIB gp160 that neutralize infectivity, block binding to CD4, and react with diverse isolates.Semantic proximity Read ↗

Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120Semantic proximity Read ↗

Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal AntibodiesSemantic proximity Read ↗

Sequential Immunization with V3 Peptides from Primary Human Immunodeficiency Virus Type 1 Produces Cross-Neutralizing Antibodies against Primary Isolates with a Matching Narrow-Neutralization Sequence MotifSemantic proximity Read ↗

A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12Semantic proximity Read ↗

The Cross-Clade Neutralizing Activity of a Human Monoclonal Antibody Is Determined by the GPGR V3 Motif of HIV Type 1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.