Article
Induction of T cells specific for the mutated segment of oncogenic P21ras protein by immunization in vivo with the oncogenic protein.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy - 1 Aug 1993
Peace D J, Smith J W, Disis M L, Chen W, Cheever M A
Abstract excerpt
Many malignancies harbor mutated ras proto-oncogenes encoding 21 kDa proteins with single amino acid substitutions. Previous studies have shown that the aberrant p21ras proteins are potential tumor-specific antigens in that CD4+ class II major histocompatibility complex-restricted T cells specifi...
Topics
- Amino Acid Sequence
- Animals
- Cell Division
- Cell Line
- Epitopes
- Female
- Immunization
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Oncogene Protein p21(ras)