Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway.

doi:10.1085/jgp.200609492

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Article

Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway.

The Journal of general physiology - 1 Jul 2006

Sack Jon T, Aldrich Richard W

Abstract excerpt

Potassium currents from voltage-gated Shaker K channels activate with a sigmoid rise. The degree of sigmoidicity in channel opening kinetics confirms that each subunit of the homotetrameric Shaker channel undergoes more than one conformational change before the channel opens. We have examined effects of two externally applied gating modifiers that reduce the sigmoidicity of channel opening. A toxin from gastropod...

Topics

Animals
Drosophila
Drosophila Proteins
Female
Ion Channel Gating
Kinetics
Membrane Potentials
Models, Chemical
Mutation
Neurotoxins
Oocytes
Patch-Clamp Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Potassium

Potassium Channel Blockers

Protein Binding

Protein Structure, Quaternary

Protein Subunits

RNA, Messenger

Source

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Identifiers

PMID: 16801385
DOI: 10.1085/jgp.200609492
PMCID: PMC2151558

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