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Article

Differentiation of heterogeneous phenotypes in human osteoblast cultures in response to 1,25-dihydroxyvitamin D3.

Bone - 1 Jan 2000

Thavarajah M, Evans D B, Kanis J A

Abstract excerpt

1,25(OH)2D3 (1,25-dihydroxyvitamin D3) inhibits the cell proliferation of human osteoblast-like cell cultures, but stimulates the synthesis of two of the phenotypic markers of the osteoblast, alkaline phosphatase and osteocalcin. It is not known whether all cells which synthesize alkaline phosphatase also synthesize osteocalcin in response to 1,25(OH)2D3. In this study we addressed this question by examining the...

Topics

Adolescent
Adult
Aged
Alkaline Phosphatase
Calcitriol
Cell Count
Cell Differentiation
Cells, Cultured
Female
Humans
Immunohistochemistry
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Osteoblasts

Osteocalcin

Phenotype

Staining and Labeling

Source

Identifiers

PMID: 7505605
DOI: 10.1016/8756-3282(93)90208-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7505605-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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