Article
Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker.
The Journal of biological chemistry - 5 Dec 1993
di Marzo Veronese F, Reitz M S, Gupta G, Robert-Guroff M, Boyer-Thompson C, Louie A, Gallo R C, Lusso P
Abstract excerpt
The third hypervariable region, or V3 loop, represents the principal neutralizing domain of the gp120 envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1). Sequential viral isolates from a laboratory worker (LW) accidentally infected with HIV-1IIIB in 1985 were analyzed using type...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Antibodies, Monoclonal
- Cell Line
- Epitopes
- Genetic Variation
- Giant Cells
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Medical Laboratory Personnel
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Insertional