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Article

Generation of neutralization-resistant HIV-1 in vitro due to amino acid interchanges of third hypervariable env region.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1990

Masuda T, Matsushita S, Kuroda M J, Kannagi M, Takatsuki K, Harada S

Abstract excerpt

Antigenic mutants of HIV-1 were isolated from three plaque-cloned viruses by the resistance of the virus to neutralizing mAb 0.5 beta against V3 domain of viral gp120, when the viruses were passaged in the presence of the antibody. However, when chronically infected MOLT-4 cells were treated with 0.5 beta mAb, recovered viruses from the 0.5 beta-treated cells showed no antigenic changes. The extent of genomic...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Base Sequence
Epitopes
HIV Envelope Protein gp120
HIV-1
Humans
Molecular Sequence Data
Mutation
Neutralization Tests

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PMID: 1700002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1700002-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Generation of neutralization-resistant HIV-1 in vitro due to amino acid interchanges of third hypervariable env region.PMID 1700002Read ↗

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