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Article

Signaling of ambient pH in Aspergillus involves a cysteine protease.

The Journal of biological chemistry - 1 Dec 1995

Denison S H, Orejas M, Arst H N

Abstract excerpt

In Aspergillus nidulans, the regulation of gene expression in response to changes in ambient pH is mediated by the PacC zinc finger transcriptional regulator. At alkaline ambient pH, PacC is proteolytically processed to a functional form serving as an activator of alkaline-expressed genes and a repressor of acid-expressed genes. This activation of PacC occurs in response to a signal mediated by the products of...

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Identifiers

PMID: 7499363
DOI: 10.1074/jbc.270.48.28519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Signaling of ambient pH in Aspergillus involves a cysteine protease.PMID 7499363Read ↗

Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety.Semantic proximity Read ↗

Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III.Semantic proximity Read ↗

Identification, cloning and analysis of the Aspergillus niger gene pacC, a wide domain regulatory gene responsive to ambient pH.Semantic proximity Read ↗

Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB.Semantic proximity Read ↗

Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.Semantic proximity Read ↗

Putative membrane components of signal transduction pathways for ambient pH regulation in Aspergillus and meiosis in saccharomyces are homologous.Semantic proximity Read ↗

Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein.Semantic proximity Read ↗

YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix.Semantic proximity Read ↗

Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor.Semantic proximity Read ↗

pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems.Semantic proximity Read ↗

The Aspergillus pH-responsive transcription factor PacC regulates virulence.Semantic proximity Read ↗

pH Response Pathways in Fungi: Adapting to Host-derived and Environmental SignalsSemantic proximity Read ↗

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