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Article

Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.

Eukaryotic cell - 1 Jun 2007

Peñas María M, Hervás-Aguilar América, Múnera-Huertas Tatiana, Reoyo Elena, Peñalva Miguel A, Arst Herbert N, Tilburn Joan

Abstract excerpt

The Aspergillus nidulans pH-responsive transcription factor PacC is modulated by limited, two-step proteolysis. The first, pH-regulated cleavage occurs in the 24-residue highly conserved "signaling protease box" in response to the alkaline pH signal. This is transduced by the Pal signaling pathway, containing the predicted calpain-like cysteine protease and likely signaling protease, PalB. In this work, we...

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Identifiers

PMID: 17416893
DOI: 10.1128/EC.00047-07
PMCID: PMC1951515

Genes

MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.PMID 17416893Read ↗

Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site, and processing occurs in yeast if pH signalling is bypassed.Semantic proximity Read ↗

Signaling of ambient pH in Aspergillus involves a cysteine protease.Semantic proximity Read ↗

Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety.Semantic proximity Read ↗

Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III.Semantic proximity Read ↗

Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc finger transcription factor PacC.Semantic proximity Read ↗

Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH.Semantic proximity Read ↗

pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems.Semantic proximity Read ↗

Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor.Semantic proximity Read ↗

Mutational analysis of the pH signal transduction component PalC of Aspergillus nidulans supports distant similarity to BRO1 domain family members.Semantic proximity Read ↗

The Aspergillus pH-responsive transcription factor PacC regulates virulence.Semantic proximity Read ↗

Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein.Semantic proximity Read ↗

YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix.Semantic proximity Read ↗

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