Article
Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety.
Genes & development - 1 Jul 1995
Orejas M, Espeso E A, Tilburn J, Sarkar S, Arst H N, Peñalva M A
Abstract excerpt
Extremes of pH are an occupational hazard for many microorganisms. In addition to efficient pH homeostasis, survival effectively requires a regulatory system tailoring the syntheses of molecules functioning beyond the cell boundaries (permeases, secreted enzymes, and exported metabolites) to the pH of the growth environment. Our previous work established that the zinc finger PacC transcription factor mediates...
Topics
- Aspergillus nidulans
- Base Sequence
- Binding Sites
- Blotting, Western
- Consensus Sequence
- Endopeptidases
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genotype
- Hydrogen-Ion Concentration