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Article

The Aspergillus pH-responsive transcription factor PacC regulates virulence.

Molecular microbiology - 1 Feb 2005

Bignell Elaine, Negrete-Urtasun Susana, Calcagno Ana Maria, Haynes Ken, Arst Herbert N, Rogers Tom

Abstract excerpt

The ability of a pathogen to adapt to the host environment is usually required for the initiation of disease. Here we have investigated the importance of the Aspergillus nidulans PacC-mediated pH response in the pathogenesis of pulmonary aspergillosis. Using mutational analysis, we demonstrate that, in neutropenic mice, elimination of the A. nidulans pH-responsive transcription factor PacC, blocking the ambient...

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Identifiers

PMID: 15686555
DOI: 10.1111/j.1365-2958.2004.04472.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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