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Article

YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix.

Molecular and cellular biology - 1 Mar 2003

Vincent Olivier, Rainbow Lynne, Tilburn Joan, Arst Herbert N, Peñalva Miguel A

Abstract excerpt

The zinc finger transcription factor PacC undergoes two-step proteolytic activation in response to alkaline ambient pH. PalA is a component of the fungal ambient pH signal transduction pathway. Its mammalian homologue AIP1/Alix interacts with the apoptosis-linked protein ALG-2. We show that both PalA and AIP1/Alix recognize a protein-protein binding motif that we denote YPXL/I, where Tyr, Pro, and Leu/Ile are...

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Identifiers

PMID: 12588984
DOI: 10.1128/MCB.23.5.1647-1655.2003
PMCID: PMC151718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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