Article
Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III.
The Journal of biological chemistry - 13 Feb 2009
Rodríguez-Galán Olga, Galindo Antonio, Hervás-Aguilar América, Arst Herbert N, Peñalva Miguel A
Abstract excerpt
Activation of the Aspergillus nidulans transcription factor PacC, which mediates ambient pH regulation of gene expression and is recruited to ESCRT-III by the Vps32-interacting scaffold PalA, involves its ambient pH-dependent C-terminal proteolysis. This reaction is almost certainly catalyzed by the PalB calpain-like protease. Here we show that PalB associates with membranes and interacts specifically and...
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